A Simple Key For cees dekker Unveiled
A Simple Key For cees dekker Unveiled
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‘The 2nd is nanopores, and that is our oldest line of investigate and that has now triggered DNA sequencers dependant on nanopores. We pull unique DNA strands via a nanopore and might then examine off the nucleotide sequence. Really just lately, we even managed to go through out just one protein for the first time using This system. But this line of exploration is don't just about acquiring instruments, but in addition about actual biological thoughts.
Our team scientific studies bacterial cell division and is aiming to represent a ‘bottom up biology’ in synthetic cells which can autonomously divide. Our key fascination lies in cell division, chromatin composition, and spatial Regulate.
Back in 1991, Sumio Iijima from the NEC Corporation had reported the synthesis of carbon nanotubes. Band framework calculations instructed that these nanotubes could show metallic band conduction. This may be an important gain around the conducting polymers we experienced explored, which were being, in actual fact, disordered semiconductors featuring basically variable-vary hopping conductivity.
Sculpting nano-electrodes with a transmission electron beam for electrical and geometrical characterization of nanoparticles.
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and to start with ever study with the dynamics DNA supercoils and the discovery of supercoil hopping
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of an individual wire bridging two electrodes
What distinguishes biology from chemistry is the fact that these factors collectively make up a dwelling program. The trick of mentioned life, I feel, lies in the interactions, the interplay of Those people molecules. The big problem regarding the origin of life remains to be unanswered. How did we at any time evolve from easy molecules in the very intricate systems we see right now? We do not know. I want to work on These types of significant, open inquiries.’
Nanopores stand for a sublime and multipurpose Software to evaluate solitary molecules. We investigation novel detection modes with stable-condition nanopores and also a variety of strategies to evaluate proteins with nanopores. Initiatives encompass the next:
‘You shouldn't just contemplate the thoughts of tomorrow, but will also consider the concerns from the day after tomorrow’
At this time, we also understood that it ought to be doable to implement one semiconducting carbon nanotube for making a transistor — and we established out to make it. We stretched person semiconducting nanotubes across metallic electrodes and used the fundamental silicon substrate for a gate electrode, developing the basic three-terminal structure of the area-effect transistor (Fig.
Considering that 2000 he moved to single-molecule biophysics and nanobiology, with exploration from scientific studies of DNA loop extrusion and supercoiling to DNA translocation through nanopores. Far more lately his investigate has focused on researching chromatin construction and mobile division with germs on chip, when he is additionally seeking to in the end Establish synthetic cells from The underside up.
Cees Dekker is Distinguished University Professor at TU Delft. Skilled being a physicist, ceesdekker he pioneered nanotechnology with a lot of discoveries on carbon nanotubes while in the nineties. Given that 2000, he moved to single-molecule biophysics and nanobiology. His present study focuses on (i) nanopores for protein sequencing; (ii) chromosome composition, especially SMC motor protein; and (iii) creating a residing synthetic cell from lifeless molecules. Dekker is an elected member of the KNAW and fellow into the APS plus the IOP.
2008, to start with observation of protein-coated DNA translocation as a result of nanopores; fixed the origin with the electrophoretic pressure on DNA in nanopores; uncovered a major velocity enhance of microtubules in electrical fields; found an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij achieved enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent layout in 2005. (nl)